I asked Prosoniq about the MPEX3 pause issue mentioned in the review of Timefactory 2 and I got this response:

I got in touch with our developers and they say that the pause you were observing is due to a bug in 2.0.0-2.0.4 that causes the MPEX3 processing latency not to be compensated for. This will be addressed in 2.0.5

There are a few good things to note here:
1) They are fast as hell to respond!
2) I wasn’t insane and didn’t do wrong.
3) They are working on a solution.

Hats off…

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EDIT (April 23rd):
It’s actually fixed now, overnight!